![]() The time from the emergency department to the operating room and the time from injury (if available) to the operating room were calculated. The age at surgery, gender, weight, and initial examination findings of skin tenting, ecchymosis, and preoperative neurologic deficit was collected. The medical charts and operative records were retrospectively reviewed. Patients with open fractures and/or vascular injury were excluded. The purpose of this study was to evaluate the outcomes and complications of Gartland type III pediatric supracondylar humerus fractures treated at a pediatric level-one trauma center over a 7-year period, specifically addressing the impact of the time to surgery on the incidence of postoperative complications and conversion to an open reduction.Īll children with closed type III supracondylar humerus fractures admitted and treated between January 2004 and December 2011 at the author’s institution were identified. With regards to operative delay leading to open reduction, there is literature supporting both arguments, resulting in a lack of conclusive agreement. showed that delayed intervention resulted in an increase in open reduction but no other perioperative complications. Multiple studies followed showing similar results. published a retrospective review comparing early versus delayed (greater than 8 h following fracture) treatment of 58 patients with type III fractures and showed no difference in terms of clinical results or perioperative complications, including conversion to open reduction. In a similar fashion, many pediatric studies have been performed questioning the necessity of urgent night-time intervention in Gartland type III supracondylar humerus fractures. In recent years, many adult trauma hospitals have decreased night-time on-call orthopedic surgery without affecting patient outcomes by allowing dedicated trauma operative time during the day. The theoretical advantage proposed that this would lead to a decrease in perioperative complications, including iatrogenic nerve palsies, compartment syndrome, and conversion to an open reduction. Until the late 1990s, it was believed that displaced pediatric supracondylar humerus fractures required emergent surgical intervention or skeletal traction. conducted a systematic review focusing on iatrogenic ulnar nerve injury due to the placement of a medial pin and concluded that the number needed to harm was 28 patients. The concern for iatrogenic ulnar nerve injury during the placement of a medial pin discourages this configuration. Biomechanical testing has demonstrated a theoretical advantage of both medial and lateral cross pinning however, these initial findings have not translated into clinical results. ![]() ![]() The focus of many recent research studies on the treatment of these fractures has been pin configuration. The current preferred treatment for Gartland type III fractures consists of attempted closed reduction and percutaneous pinning. Gartland originally described a classification for extension-type supracondylar humerus fractures, dividing them into three types: type I is non-displaced, type II is displaced with an intact posterior cortex, and type III is displaced without cortical contact. The majority of these fractures (96–98 %) are extension-type fractures. Supracondylar fractures of the humerus are the most common fracture of the elbow in children. ![]()
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![]() ![]() ![]() Enjoy stunning HD resolution thanks to the latest in DLP. Its picture is also much better in pretty much every way, so if you're looking for a projector for use around the home, or maybe backyard, and you don't need battery power, it's worth considering. Incredible brightness and clarity from a super portable projector. Read our Anker Nebula Cosmos Laser 4K Projector review.īenQ HT2050A: The HT2050 isn't technically a portable projector at all, but it is compact and roughly the same price as one of the more expensive "portable" options. It's nice and bright, but the other downsides - lack of zoom, average overall image quality and a steep price for what you get - keep it off this list. The Best Portable Mini Projector By Adrienne Maxwell Updated Photo: Michael Hession FYI Xgimi has replaced our former top pick, the MoGo Pro, with the MoGo 2 and MoGo 2 Pro. There's also no battery so you'll need to plug it in. Read our Xiaomi Mi Smart Projector 2 review.Īnker Nebula Cosmos Laser 4K: Since it has a handle and a compact size, the Cosmos Laser 4K is technically portable, but it's hardly mini at more than 10 pounds. It's relatively dim, especially for the price, and it lacks both a built-in battery and compatibility with a USB power source, so it's not truly portable. We appreciated the compact size, 1080p resolution and built-in Android TV streaming, but the cons outweigh the pros. VANKYO Leisure 430W Mini Wi-Fi Projector, Full HD 1080P Supported Projector with Synchronize Smart Phone Screen, Video Portable Projector Compatible with. Make the most of the outdoors this year with one of the best portable projectors Comments Included in this guide: 1 LG CineBeam HU80KSW View 2 BenQ GS50 1080p Wireless Projector Check Price 3. Xiaomi Mi Smart Projector 2: Another relatively expensive small projector we didn't love, the Xiaomi at least has a gorgeous, Apple-like design going for it. 15 hours ago &0183 &32 AuKing Projector, 2023 Upgraded Mini Projector, 9500 lumens Multimedia Home Theater Video Projector, Compatible with Full HD 1080P. ![]() ![]() Utah gets sucked into the wave and faints, but the other surfer bails and rescues Utah. They reach France and Utah gets help from others to surf the tall tube wave.Īs he goes in, there is already another surfer riding the wave, leaving Utah unstable. After presenting his analysis, Utah is sent undercover to France under a field agent named Angelo Pappas ( Ray Winstone). They have already completed three, and Utah predicts they'll attempt the fourth on a rare sea wave phenomenon in France. Utah's research concludes that they were done by the same men, who are attempting to complete the Ozaki 8, a list of eight extreme ordeals to honor the forces of nature. A similar heist happens over Mexico where the criminals unload millions of dollars in bills, then disappear into the Cave of Swallows. He attends a briefing on a skyscraper heist, in which the criminals stole diamonds, escaping by parachute, in Mumbai. Seven years later, Utah is an FBI agent candidate. The run ends with a jump onto a lone stone column, where Jeff overshoots the landing and falls to his death. The film received negative reviews from critics, and grossed $133 million from a $105 million budget.Įxtreme sport athlete Johnny Utah ( Luke Bracey), and his friend Jeff ( Max Thieriot), are traversing a steep ridgeline on motorbikes. The film stars Édgar Ramírez, Luke Bracey, Teresa Palmer, Delroy Lindo and Ray Winstone, and was released in China on December 4, 2015, by China Film Group and in the United States on December 25, 2015, by Warner Bros. An American-German-Chinese co-production, the film is a remake of the 1991 film of the same name. Kosove, Christopher Taylor and David Valdes. ![]() ![]() Point Break is a 2015 action-thriller film directed and shot by Ericson Core and written by Kurt Wimmer which he co-produced with John Baldecchi, Broderick Johnson, Andrew A. ![]() ![]() Vague Rant on RetroArch 1.4.1 Major Changes Detailed Tatsuya79 on RetroArch 1.4.1 Major Changes Detailed Nucleoprotein on Mednafen/Beetle PSX PGXP arrives Barney the Dinosaur on RetroArch, Libretro core license violations by Hyperkin’s Retron5 Sean Cahill on RetroArch 1.3.2. That might change in the future and there are some decent standalone NES and SNES emulators but its not doing anything that other consoles, Androids, PCs can do better. Use the arrow keys to navigate the menu, and press Enter to make a selection. RetroArch 1.15.0 release Lakka 4.3 release Recent Comments. Scoby Tech 35.6K subscribers 123K views 2 years ago Retroarch Tutorial - Android Hey, guys, my name is Scoby Tech and in today's video, I am going to be showing you how to Setup and Map a. So TLDR PS4 / PS4 Pro is not a great emulation solution. This means that from Day One we have a fully. PS4 PCSX-R (PlayStation 1 Emulator) BETA 2. The PlayStation4 port is using a homebrew SDK called liborbis, and thanks to this SDK we are able to use OpenGLES 2 on the PS4. Native port of RetroArch on the PS4 (Unofficial port) 5 / 5, 1 rating. N64 ran horribly which can be partially attributed to the terrible CPU of the PS4 / PS4 Pro (and for context it runs just as badly on Xbox One X). RetroArch has been ported to PlayStation4 by Frangarcj, Big Boss and others A few cores have been ported and have been confirmed running already, such as SameBoy and 2048. It enables you to run classic games on a wide range of computers and consoles through. ![]() If a game is locked at 30 FPS, such as Sonic Adventure for Dreamcast / Flycast core, it will more or less work fine and that game worked pretty well. RetroArch is a frontend for emulators, game engines and media players. It is really jarring and one of the worst ways you can play retro games. NES, SNES, Genesis, GBA will run full speed and will try to target 60 FPS but it drops to 30 FPS at a regular interval every few seconds. The reason for that is there are MAJOR frame pacing issues with it. With that said I tested this unofficial build and its rough. Do be aware that the current iteration of Retroarch that is available for PS4 is an unofficial fork, there is no official build of Retroarch for PS4 yet. ![]() ![]() ![]()
![]() ![]() Streamlabs OBS is the best YouTube streaming software because it has more templates and live chat widgets. It has its own Facebook integration facility. Where do you want your audiences tuned in?Įach program is optimized for a certain platform, but all 8 solutions on our list can qualify as the best Twitch streaming software.īut if you’re specifically looking for a Facebook Live streaming software, Wirecast is the top candidate. It has a pre-recorded streaming feature, so it’s best used for lifestyle vlogs or home videos. Large-scale productions such as events, variety shows, sports, and conferences are best done in vMix.Īnd for personal use, go for Onestream. If you’re a social media marketer aiming to drive business growth with your live content, we suggest using Streamlabs OBS and Lightstream creator studios. If it’s to showcase your gaming skills, then a game streaming software like Xsplit Broadcaster, Wirecast, OBS Studio, and Twitch Studio has the best interface to support that. What type of content are you live streaming? ![]() So here’s what you should consider in choosing the best live streaming service: Use Cases It also lets you add several production elements to your broadcasts such as overlays, graphics, transitions, and more! How to Choose the Best Streaming Software?Īs a streamer, you want to put on a great show and deliver a smooth viewing experience for your audience. The program works as an encoder of video inputs and distributes them digitally to online streaming platforms like Twitch, YouTube, Facebook, etc. It’s a lot like airing a television program, but in this setup, you don’t need to rely on broadcasting schedules and commercial spots. They’re what you use to broadcast video-on-demand content. With this, the demand for the best streaming software is quickly picking up!īut what can these software do anyway? Simple. As we speak, there are already 8.55 million active Twitch streamers globally, as shown in Statista’s report. For comparison, there were only 3.8 million streamers in February 2020. This would be compatible with both 32 bit and 64 bit windows.Live streaming took the entertainment industry by storm. ![]() This is complete offline installer and standalone setup for Wirecast. Processor: Intel Dual Core processor or higher.Ĭlick on below button to start Wirecast Free Download.Hard Disk Space: 200MB of free space required.Latest Version Release Added On: 7th Mar 2015īefore you start Wirecast free download, make sure your PC meets minimum system requirements.Compatibility Architecture: 32 Bit (x86) / 64 Bit (圆4).Setup Type: Offline Installer / Full Standalone Setup.can crop the unwanted portions from the videos.Can adjust the opacity level of the videos.Can edit your videos before broadcasting.Can broadcast you images and videos live on internet.Features of Wirecastīelow are some noticeable features which you’ll experience after Wirecast free download. You can also Download Man圜am pro which is another great tool.Īll in all Wirecast is a handy application which will let you broadcast your images and videos live on the internet. Twitter feed is also supported and you can add Twitter messages in your live shows. This captured layer can then be edited by slowing it down or speeding up. During the live streaming all you need to do is to press the replay button and capture the video content on master layer. Wirecast also got an audio preview by which you can check your audio before it goes live Wirecast also lets you capture and replay your live streaming. The frame rate of your videos can also be adjusted. You can also flip your videos and adjust the opacity level. You can also Download Ace Stream Media which is another amazing tool of such type. Before broadcasting it you can edit your content as well like you can crop the unwanted portions from the video and present the content which suits you the best. You can also import media files from your computer and then broadcast it on web. Wincast has got a built in Desktop Presenter which will allow you to stream your desktop screen on web. this program is very easy to use but you may require to go through different tutorials provided by the developers in order to get the most out of it. Now you can broadcast videos from your desktop to the whole world. Wirecast is an application developed by Telestream which will empower you with live broadcasting capabilities. It is full offline installer standalone setup of Wirecast for Windows 32 bit 64 bit PC. Wirecast Free Download Latest Version setup for Windows. ![]() ![]() ![]() Released last month, Borderlands 2 was the biggest-selling launch of the year until the release of FIFA 13. Borderlands 2 - Captain Scarlett and her Pirates Booty - Trophy Guide & Road Map - Captain Scarlett and Her Pirates Booty - If this guide was helpful and you would like to join the forums, please feel free to give me a referral by clicking here. The Season Pass, meanwhile, can be picked up for $29.99 (£18.90) on PS3 and PC, and 2400 Microsoft Points (£20 / $30) on Xbox 360. It can be purchased individually, or with the discounted Borderlands 2 season pass.Įach pack costs $9.99 (£6.30) on PC and PS3 and 800 Microsoft Points (£6.80 / $10) on the Xbox 360. Theres still more than enough to do in Borderlands 2 even without DLC, but, the first expansion campaign has launched as of this morning for XBLA. The pack is the first of four pieces of campaign DLC releasing between now and June 2013. That kicks off this whole adventure that the players can go on." You can repeat the quest from the board to get the 'treasure' a second time, but Im still unsure if that is a daily or if you can only do it twice, as. Correct, its a quest reward for finishing the DLC, you get the head for the character youre playing. These bandits have really embraced the pirate lifestyle, and there's the legend of a treasure. Soooo that means if you want all the heads, youll have to do the DLC as every character. She seeks a treasure and already knows where to find two of the four compass pieces needed to locate the treasure. It feels more like Tatooine than an ocean. How to unlock the Gadabout achievement in Borderlands 2 (Xbox 360): Discover all named locations in Oasis and the surrounding Pirates Booty zones. 4 Quotes 5 Trivia 6 Gallery Captain Scarlett, originally from the planet Eunomia, is the titular NPC and the main antagonist of Captain Scarlett and Her Pirate's Booty, the first DLC for Borderlands 2. Likening the new environment to Tatooine from Star Wars, Gearbox president Randy Pitchford said: "You can sense the pirate theme across the landscape, even though there's no water. Find ECHOs, Cult of the Vault locations, Red Chests & more Use the progress tracker to get. It also features a new currency called seraph crystals. Interactive Map of Borderlands 2 collectibles and boss spawns. The Expansion was announced on October 11, 2012, and was released for PC, Xbox 360, and the PlayStation 3 on October 16, 2012. Borderlands 2 will receive a new pirate-themed DLC pack next week, Gearbox has confirmed.ĭiscovered earlier this week, 'Captain Scarlett and Her Pirate's Booty' takes place in an expansive desert, which houses a shanty town called Oasis.Ĭentred around a one-eyed pirate named Captain Scarlett, the campaign introduces a new sand skiff vehicle, as well as enemies such as sand worms. Captain Scarlett and her Pirate's Booty, by Gearbox Software and Triptych Games, is the first in a series of downloadable expansion packs for Borderlands 2. ![]() ![]() ![]() The additional funding not allocated by the Joint Explanatory Statement to specified PPAs in the five appropriations is subdivided into numerous categories and subcategories within these broad areas: "The Army Civil Works FY 2022 Work Plan is yet another increment of transformative investments during this administration that will yield high economic and environmental returns, by supporting the use of the nation’s waterways and ports to strengthen supply chains building resilience to climate change to protect people and infrastructure and increasing opportunities to work with and support disadvantaged communities,” said The Honorable Michael Connor, Assistant Secretary of the Army for Civil Works. It also funds programs that contribute to the protection of the nation’s waters and wetlands the generation of low-cost renewable hydropower the restoration of certain sites contaminated as a result of the nation’s early atomic weapons development program and emergency preparedness and training to respond to natural disasters. ![]() The Army Civil Works program funds the planning, design, construction, and operation and maintenance of water resources projects, with a focus on the highest performing work within the three main Civil Works mission areas: commercial navigation, flood and storm damage reduction, and aquatic ecosystem restoration. The allocation of these additional funds is presented in the Work Plan. The USACE is responsible for allocating the remainder in these accounts, approximately $1.1 billion, to specific PPA, consistent with the categories, subcategories, and other direction provided in the Joint Explanatory Statement. The Joint Explanatory Statement – Division D report, Title I – Corps of Engineers – Civil, Department of the Army (Joint Explanatory Statement) that accompanies the Act allocates approximately $6.8 billion of the total for these five accounts to specific Programs, Projects and Activities (PPA). Of the $8.3 billion in appropriations provided for the Army Civil Works program, approximately $7.9 billion is appropriated in five accounts: Investigations Construction Operation and Maintenance Mississippi River and Tributaries and the Formerly Utilized Sites Remedial Action Program (FUSRAP). On March 15, 2022, President Biden signed into law the Consolidated Appropriations Act, 2022, Public Law 117-103, of which Division D is the Energy and Water Development and Related Agencies Appropriations Act, 2022 (Act). Army Corps of Engineers (USACE) delivered to Congress its Fiscal Year 2022 (FY 2022) Work Plan for the Army Civil Works program on May 25, 2022. ![]() ![]() Second, full-length cDNA sequencing could be used to accurately determine the sequence and identity of alleles of HLA genes. Determining isoform-level transcriptomes of healthy and cancerous immune cells might inform treatment decisions and future However, evidence is accumulating that these epitopes might be absent in some isoforms expressed by these genes ( Sotillo et al. Leukemia (B-ALL) target epitopes of CD19, CD20, and CD22 ( Davila and Brentjens 2016 Fry et al. For example, current antibody and chimeric antigen receptor (CAR) T cell therapies against B cell acute lymphoblastic (1) the isoforms of surface receptors targeted in immunotherapy, (2) allele-resolved HLA transcript sequences central to self/non-self-discrimination,Īnd (3) B cell receptor (BCR) and T cell receptor (TCR) repertoires instrumental to the adaptive immune response to pathogens.įirst, full-length cDNA sequencing should be capable of investigating the transcript isoforms of surface receptors expressedīy B cells which have important roles in the immune response but are also themselves targets in the treatment of B cell–derived Accurate and deep full-length cDNA sequencing of immune cell transcriptomes could overcome this shortfall by providing However, RNA-seq, the current gold-standard for whole-transcriptome analysis, falls short of describing these immune receptorsĬompletely and accurately ( Mose et al. The transcriptsĮncoding these immune receptors are of great interest to basic and translational research as well as diagnostic and otherĬlinical purposes ( Logan et al. The human immune system relies on highly diverse and complex receptors to protect us from a wide array of pathogens. The HLA and AIRRĪnalysis approaches we introduce here are untargeted and therefore do not require prior knowledge of the composition or genetic Sequences of HLA alleles, and (3) extract detailed AIRR data for the analysis of the adaptive immune system. We used this data set to (1) show that deep and accurate full-lengthĬDNA sequencing can be used to provide isoform-level transcriptome analysis for more than 9000 loci, (2) generate accurate Generated over 10,000,000 full-length cDNA sequences at a median accuracy of 97.9% using our nanopore sequencing-based RollingĬircle Amplification to Concatemeric Consensus (R2C2) protocol. Sequencing (AIRR-seq) currently rely on our incomplete knowledge of the genetic diversity at HLA and BCR/TCR loci. Both short-read RNA-seq-based HLA typing and BCR/TCR repertoire Individual carry a vast amount of health-relevant information. In turn, the repertoires of millions of unique BCR and TCR transcripts in each In organ and bone marrow transplantations. Determining which allelesĪn individual possesses for each HLA gene (high-resolution HLA typing) is essential to establish donor–recipient compatibility These include transcriptsĮncoding human leukocyte antigen (HLA) receptors as well as B cell and T cell receptors (BCR and TCR). Together these studies further our understanding of the relationship between immune repertoire diversity and immune function.The human immune system relies on highly complex and diverse transcripts and the proteins they encode. Lastly, I explore the hypothesis that chronic cytomegalovirus infection in the elderly compromises immune function by reducing CD8+ T cell repertoire diversity. To study the diversity of the T cell repertoire in response to an acute infection, I combine live-attenuated yellow fever virus vaccination and T cell repertoire sequencing to identify and track vaccine responsive clones longitudinally. I also present two studies exploring the diversity of the T cell repertoire in acute and chronic viral infections. In this work, I present a database of B cell receptor sequences that unites experimental and computational techniques to accurately estimate the richness of the naïve and memory B cell repertoires. As a result, the diversity of B and T cell receptors in the body determine an individual's ability to respond to new and previously seen antigens. The combination of different (Variable, Diversity and Joining) gene segments, insertion and deletion of non-templated nucleotides at the junctions between segments and pairing of heavy and light chains control the specificity of recognition. The vast majority of B and T cell clones possess a single unique heterodimeric receptor with a highly diverse binding domain generated through ordered somatic gene rearrangements known as V(D)J recombination. Immunoglobulin and T cell receptors enable the immune system to recognize an enormous set of exogenous and endogenous antigens. B and T lymphocytes are the cellular effectors of the adaptive immune system and perform the learning and recall functions that are the basis of immunological memory. ![]() ![]() The Bottom Line: 9 trips over the caramel river and through the coffee woods out of 10 Simply put, if you like caramel, Dunkin’ has something here to further spread your horizons like the long auburn sinew of a Snickers bar torn in half. If I had one critique, it’s that after eating a lot of it, a sort of caramel stickiness does tend to glaze on the back of your palate, somewhat muddling the otherwise clear medley of taste bud experiences, but that’s not enough to ruin the experience. Even as a corn-based cereal, I couldn’t taste any of that pesky grain, further allowing the layers of flavor to shine. Especially in milk (or in well-creamed coffee), Caramel Macchiato’s many elements start to swim together beautifully. I’m not always a fan of cramming marshmallows into every cereal, either, but for the first time in recent memory, Dunkin’ marbits add a believable pop of “whipped cream” to give this stuff the playfully sweet edge the caramel may have lacked. If you aren’t a fan of coffee, I wouldn’t rule this one out entirely, as the coffee notes are far more level-headed than bitter, only serving to give greater depth to an already well thought out caramel overtone. Far from the syrupy swill you’d expect in a hyper-sugary caramel coffee beverage, Caramel Macchiato keeps it real with a satisfying balance of sweetness and woodsiness. Deeply caramelized and with an earthy amber sweetness, the caramel here pairs beautifully with the subtle undertones of roasted Dunkin’ coffee. See what I did there? Yes, if I could compare Dunkin’s to any other caramel cereal, it would be General Mills’ Girl Scouts Caramel Crunch-albeit a more souped up one. And while Dunkin’ Caramel Macchiato Cereal has close contemporary analogues, it’s also a deLite of its own. For one seemingly simple flavor, every cereal approaches it differently. Dunkin’ Caramel Macchiato Cereal ReviewĬaramel cereals always leave me a little apprehensive. Sure, Dunkin’ cereals only contain 1/10th the caffeine of a cup of coffee per serving, but if my own childhood cereal consumption velocity is any indication, those perky percentiles will add up fast-the length of a single SpongeBob episode kind of fast.īut enough pep talk, let’s simultaneously eat and drink our breakfast. Yes, it is this last point that makes Dunkin’ cereals so significant-there have been mainstream coffee-flavored cereals before, but none that dared bring real bouncy bean juice into a supermarket aisle already known for sugar-rushing young kids: the last demographic that needs more energy. ![]() ![]() Granted, these two new cereals are based on coffee drinks rather than doughnuts, but that simply gives you an excuse to dunk a real cruller in your caffeinated cereal endmilk. ![]() Not since the egg predated the chicken has such a causality dilemma been posed: “but first, cereal” or “but first, coffee”? I’m sure you’ve seen the latter phrase emblazoned on countless Etsy shirts and flea market embroideries-right next to the Live, Laugh, Love pillows and fat chicken kitchen décor-but with cereal serving as a perfect toothsome preface to just about any activity, sometimes one can face cognitive gridlock when forced to choose between a warm mugful and a cold-milked bowlful.īut worry no longer, crunchy koan ponderers, because Post & Dunkin’ have teamed up to reanimate the Donut-slinging brand’s cereal division, which has laid dormant since Ralston stopped making their chocolate and glazed goodies in the late ’80s. ![]() |
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